Computational analysis of open loop handwriting movements in Parkinson's disease: A rapid method to detect dopamimetic effects
Identifieur interne : 005673 ( Main/Exploration ); précédent : 005672; suivant : 005674Computational analysis of open loop handwriting movements in Parkinson's disease: A rapid method to detect dopamimetic effects
Auteurs : Eichhorn [Allemagne] ; T. Gasser [Allemagne] ; N. Mai [Allemagne] ; C. Marquardt [Allemagne] ; G. Arnold [Allemagne] ; J. Schwarz [Allemagne] ; W. H. Oertel [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 1996-05.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Apomorphine, Apomorphine (administration & dosage), Apomorphine (adverse effects), Brain (drug effects), Brain (physiopathology), Carbidopa (administration & dosage), Carbidopa (adverse effects), Computational analysis, Drug Therapy, Combination, Female, Handwriting, Handwriting movements, Humans, Levodopa (administration & dosage), Levodopa (adverse effects), Male, Microcomputers, Middle Aged, Neurologic Examination (drug effects), Neurologic Examination (instrumentation), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease, Secondary (drug therapy), Parkinson Disease, Secondary (etiology), Parkinson Disease, Secondary (physiopathology), Parkinson's disease, Signal Processing, Computer-Assisted (instrumentation), Treatment Outcome, Unified Parkinson's disease Rating Scale.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Apomorphine, Carbidopa, Levodopa.
- chemical , adverse effects : Antiparkinson Agents, Apomorphine, Carbidopa, Levodopa.
- drug effects : Brain, Neurologic Examination.
- drug therapy : Parkinson Disease, Parkinson Disease, Secondary.
- etiology : Parkinson Disease, Secondary.
- instrumentation : Neurologic Examination, Signal Processing, Computer-Assisted.
- physiopathology : Brain, Parkinson Disease, Parkinson Disease, Secondary.
- Adult, Aged, Drug Therapy, Combination, Female, Handwriting, Humans, Male, Microcomputers, Middle Aged, Treatment Outcome.
Abstract
We used a computational analysis of open loop handwriting movements and a clinical rating scale for monitoring the effect of apomorphine in 16 patients with early untreated parkinsonism [subsequently L‐DOPA responsive, probable Parkinson's disease (PD)], six patients with long‐standing PD with L‐DOPA associated motor fluctuations, and seven patients with known L‐DOPA unresponsive parkinsonism. Subjects were instructed to write fluently concentric circles of ∼ 12 mm in diameter. Movements were recorded for two periods of 3 a each, using a digitizing tablet. Mean Peak velocity (Vmax) and mean peak acceleration (Amax) were determined. In addition, two sensitive indices describing the degree of automation of handwriting were derived: (a) NCV, calculated as the mean Number of Changes in direction of Velocity per half circle, and (b) NCA, the mean Number of Changes in the direction of Acceleration. Clinical rating was performed according to the Unified Parkinson's disease Rating Scale part III (UPDRS III). After apomorphine injection, the patients with early untreated probable PD showed significant improvement of Vmax' Amax' NCV, NCA, and UPDRS III scores. Likewise, the patients with long‐standing PD improved significantly in all kinematic parameters and UPDRS III scores. Patients with L‐DOPA unresponsive parkinsonism failed to change significantly in any of the parameters tested. These observations suggest that the computer‐assisted analysis of automated handwriting movements can be used as an objective quick method for quantifying dopamimetic effects on the kinematics of handwriting movements in parkinsonian patients.
Url:
DOI: 10.1002/mds.870110313
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1996-05">1996-05</date><biblScope unit="vol">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="289">289</biblScope><biblScope unit="page" to="297">297</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F4F4E98006AAE8B5B3A9870504E52D08C287DF6E</idno><idno type="DOI">10.1002/mds.870110313</idno><idno type="ArticleID">MDS870110313</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (adverse effects)</term><term>Apomorphine</term><term>Apomorphine (administration & dosage)</term><term>Apomorphine (adverse effects)</term><term>Brain (drug effects)</term><term>Brain (physiopathology)</term><term>Carbidopa (administration & dosage)</term><term>Carbidopa (adverse effects)</term><term>Computational analysis</term><term>Drug Therapy, Combination</term><term>Female</term><term>Handwriting</term><term>Handwriting movements</term><term>Humans</term><term>Levodopa (administration & dosage)</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Microcomputers</term><term>Middle Aged</term><term>Neurologic Examination (drug effects)</term><term>Neurologic Examination (instrumentation)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease, Secondary (drug therapy)</term><term>Parkinson Disease, Secondary (etiology)</term><term>Parkinson Disease, Secondary (physiopathology)</term><term>Parkinson's disease</term><term>Signal Processing, Computer-Assisted (instrumentation)</term><term>Treatment Outcome</term><term>Unified Parkinson's disease Rating Scale</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>Apomorphine</term><term>Carbidopa</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Apomorphine</term><term>Carbidopa</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term><term>Neurologic Examination</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Neurologic Examination</term><term>Signal Processing, Computer-Assisted</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Drug Therapy, Combination</term><term>Female</term><term>Handwriting</term><term>Humans</term><term>Male</term><term>Microcomputers</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We used a computational analysis of open loop handwriting movements and a clinical rating scale for monitoring the effect of apomorphine in 16 patients with early untreated parkinsonism [subsequently L‐DOPA responsive, probable Parkinson's disease (PD)], six patients with long‐standing PD with L‐DOPA associated motor fluctuations, and seven patients with known L‐DOPA unresponsive parkinsonism. Subjects were instructed to write fluently concentric circles of ∼ 12 mm in diameter. Movements were recorded for two periods of 3 a each, using a digitizing tablet. Mean Peak velocity (Vmax) and mean peak acceleration (Amax) were determined. In addition, two sensitive indices describing the degree of automation of handwriting were derived: (a) NCV, calculated as the mean Number of Changes in direction of Velocity per half circle, and (b) NCA, the mean Number of Changes in the direction of Acceleration. Clinical rating was performed according to the Unified Parkinson's disease Rating Scale part III (UPDRS III). After apomorphine injection, the patients with early untreated probable PD showed significant improvement of Vmax' Amax' NCV, NCA, and UPDRS III scores. Likewise, the patients with long‐standing PD improved significantly in all kinematic parameters and UPDRS III scores. Patients with L‐DOPA unresponsive parkinsonism failed to change significantly in any of the parameters tested. These observations suggest that the computer‐assisted analysis of automated handwriting movements can be used as an objective quick method for quantifying dopamimetic effects on the kinematics of handwriting movements in parkinsonian patients.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Eichhorn" sort="Eichhorn" uniqKey="Eichhorn" last="Eichhorn">Eichhorn</name></region><name sortKey="Arnold, G" sort="Arnold, G" uniqKey="Arnold G" first="G." last="Arnold">G. Arnold</name><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T." last="Gasser">T. Gasser</name><name sortKey="Mai, N" sort="Mai, N" uniqKey="Mai N" first="N." last="Mai">N. Mai</name><name sortKey="Mai, N" sort="Mai, N" uniqKey="Mai N" first="N." last="Mai">N. Mai</name><name sortKey="Marquardt, C" sort="Marquardt, C" uniqKey="Marquardt C" first="C." last="Marquardt">C. Marquardt</name><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W. H." last="Oertel">W. H. Oertel</name><name sortKey="Schwarz, J" sort="Schwarz, J" uniqKey="Schwarz J" first="J." last="Schwarz">J. Schwarz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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